Tadalafil has a different binding-mode than Sildenafil or Vardenafil, which are structurally very similar. The section is confusing; it talks about Pfizer as if it were a drug, whereas Pfizer is the company that owns Viagra. The statement that Cialis works for up to 36 hours occurs twice Sexual Dysfunction the last two sentences. And the whole thing needs to sourced. Corrected the confusion between company Pfizer and drug Viagra. The statement about the effect duration impotence on the half-life of the substance. Both the mesured halfe-life and the advertised effect duration can be found in any drug data base. The few public I know are in french.